解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22037
更新日期:2009-07-01 00:00:00
abstract::Previous studies have suggested that sensory mechanisms may be important components of addiction to, and withdrawal from, cigarette smoking. The sensory and respiratory responses to nicotine are mediated, in part, by bronchopulmonary C-fiber afferents. Nicotine has a direct stimulatory effect on pulmonary sensory neur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21967
更新日期:2009-05-15 00:00:00
abstract::Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a well-defined chemokine implicated in the pathology of various neurodegenerative diseases and brain injuries, such as Alzheimer's disease, multiple sclerosis, stroke, and traumatic injury. We investigated the effect of the activation of P2 purinoceptors on MCP-1 pro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21982
更新日期:2009-05-15 00:00:00
abstract::An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21950
更新日期:2009-05-01 00:00:00
abstract::One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21954
更新日期:2009-05-01 00:00:00
abstract::Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21920
更新日期:2009-04-01 00:00:00
abstract::We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected to bilateral common carotid artery stenosis with external microco...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21925
更新日期:2009-04-01 00:00:00
abstract::CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 differen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21935
更新日期:2009-04-01 00:00:00
abstract::Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21937
更新日期:2009-04-01 00:00:00
abstract::Antiglycolipid IgM antibodies are known to induce formation of "wide spaced" or "expanded" myelin, a distinctive form of dysmyelination characterized by a repeat period approximately two or three times normal, which is seen also in diseases, including multiple sclerosis. To determine whether an antibody directed again...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21914
更新日期:2009-03-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease caused by the selective death of motor neurons. Between 5% and 10% of ALS patients have a genetically inherited form of the disease known as familial ALS (FALS), and approximately 20% of FALS patients have mutations in the SOD1 gene. Although the m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21902
更新日期:2009-03-01 00:00:00
abstract::We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats r...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21900
更新日期:2009-03-01 00:00:00
abstract::Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond to any kind of damage or pathophysiological changes. These cells sense and rapidly respond to danger and inflammatory signals by changing their cell morphology; by release of cytokines, chemok...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21875
更新日期:2009-02-15 00:00:00
abstract::We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) beginning at postinjury ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21893
更新日期:2009-02-15 00:00:00
abstract::We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21885
更新日期:2009-02-15 00:00:00
abstract::BACE1 initiates processing of the amyloid precursor protein (APP) in the production of amyloid beta (Abeta) peptide. After beta-cleavage by BACE1, the C-terminal stub of the APP fragment is further processed by the gamma-secretase complex to produce Abeta. Because APP, Abeta, the gamma-secretase complex, and BACE1 are...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21858
更新日期:2009-02-01 00:00:00
abstract::We used the Plp1-overexpressing transgenic mouse model to investigate whether progressive demyelination of axons results in adaptive changes involving mitochondria within the axons. These models have myelinated axons from birth but gradually lose myelin and develop axonal loss associated with progressive neurological ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21867
更新日期:2009-02-01 00:00:00
abstract::There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21854
更新日期:2009-02-01 00:00:00
abstract::Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21823
更新日期:2009-01-01 00:00:00
abstract::The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21838
更新日期:2009-01-01 00:00:00
abstract::The inward-rectifier K(+) channel Kir4.1 is responsible for maintaining cochlear homeostasis and restoring neural excitability. The large-conductance calcium-activated K(+) channel (BK(Ca)) plays a key role in phase locking signals in the mammalian inner ear. To evaluate the influence of mitochondrial dysfunction on t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21842
更新日期:2009-01-01 00:00:00
abstract::Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 microM, 4 days) up-regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil-induced neuroprotection in neurons chronically treated wi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21798
更新日期:2008-12-01 00:00:00
abstract::Lead is putatively regarded as an environmental neurotoxicant. Long-term low-level lead exposure causes cognitive deficits, but the mechanism remains to be elucidated. In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21804
更新日期:2008-12-01 00:00:00
abstract::Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21784
更新日期:2008-11-15 00:00:00
abstract::Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21754
更新日期:2008-11-01 00:00:00
abstract::Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21757
更新日期:2008-11-01 00:00:00
abstract::In the rat brain, a heteromeric association between adenosine A(1) and purinergic P2Y(1) receptors has been demonstrated. It is suggested that this association plays an important role in the control of purine-mediated responses during pathophysiological conditions. Recently, we have demonstrated that these receptors c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21727
更新日期:2008-10-01 00:00:00
abstract::Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21715
更新日期:2008-09-01 00:00:00
abstract::Small-diameter myelinated CNS axons are preferentially affected in multiple sclerosis (MS) and in the hereditary spastic paraplegias (HSP), in which the distal axon degenerates. Mitochondrial dysfunction has been implicated in the pathogenesis of these and other disorders involving axonal degeneration. The aim of this...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21672
更新日期:2008-08-01 00:00:00
abstract::The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated in PC12E2 cells and pr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21678
更新日期:2008-08-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) plays an important role in the differentiation, development, and survival of neural stem cells. In this study, we analyzed its effects on the stimulation of human umbilical cord blood-derived mesenchymal stem cells in terms of their potential to differentiate into neuron-like c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21669
更新日期:2008-08-01 00:00:00
abstract::Although proteins belonging to the sHSP superfamily are diverse in sequence and size, most share characteristic features, including 1) a small molecular mass of 12-43 kDa, 2) a conserved alpha-crystallin domain of 80-100 residues, 3) formation of large oligomers, 4) a dynamic quaternary structure, and 5) induction by ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21682
更新日期:2008-08-01 00:00:00
abstract::Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21644
更新日期:2008-07-01 00:00:00
abstract::Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21654
更新日期:2008-07-01 00:00:00
abstract::Nociceptive neuronal activation in subcortical regions has not been well investigated in functional magnetic resonance imaging (fMRI) studies. The present report aimed to use the blood oxygenation level-dependent (BOLD) fMRI technique to map nociceptive responses in both subcortical and cortical regions by employing a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21638
更新日期:2008-06-01 00:00:00
abstract::Hippocalcin is a Ca2+-binding protein that is expressed mainly in pyramidal nerve cells of the hippocampus. However, its functions and mechanism in the brain remain unclear. To elucidate the role of hippocalcin, we used a conditionally immortalized hippocampal cell line (H19-7) and showed that bFGF treatment increased...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21602
更新日期:2008-05-15 00:00:00
abstract::Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postn...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21607
更新日期:2008-05-15 00:00:00
abstract::In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21619
更新日期:2008-05-15 00:00:00
abstract::Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21597
更新日期:2008-05-01 00:00:00
abstract::Mitochondria are power organelles generating biochemical energy, ATP, in the cell. Mitochondria play a variety of roles, including integrating extracellular signals and executing critical intracellular events, such as neuronal cell survival and death. Increasing evidence suggests that a cross-talk mechanism between mi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21564
更新日期:2008-04-01 00:00:00